Health News - Sunday, April 8, 2007
While nicotine is highly addictive, researchers have also shown the drug to enhance learning and memory-a property that has launched efforts to develop nicotine-like drugs to treat cognitive deficits in Alzheimer's and Parkinson's diseases, schizophrenia, and attention-deficit/hyperactivity disorder.
A key problem in designing such drugs has been that little was known about the detailed mechanism by which nicotine exerts its learning-enhancing effects. Now, researchers have discovered important details of how nicotine adjusts the signaling properties of neuronal wiring to enhance memory. Such signaling properties include the strength of the connections by which one neuron triggers another. Huibert Mansvelder and colleagues reported their findings in the April 5, 2007, issue of the journal Neuron, published by Cell Press. Continue reading