PureCalm by Native Remedies helps to reduce stress-related tension, restlessness, and anxiety symptoms. It is recommended for support of nervous system.

PureCalm is non-addictive aid for:

  • Anxiety and nervousness
  • Stress and tension
  • Panic attacks
  • Restlessness
  • Irritability

PureCalm Ingredients: Review of Scientific Evidence

PureCalm is a herbal blend of lemon balm, passion flower and lavender. HealthAssist has found scientific studies confirming the effectiveness of its herbal components. Take a look and make you own decision if this anti-anxiety product worth a try.

  • 1. Melissa officinalis (Lemon Balm)
    Lemon balm is classified as a stimulating nervine, or nerve tonic, with anxiolytic, anti-agitation, and antidepressant-like effects. It is used to reduce stress and anxiety, promote sleep, improve appetite, and ease pain and discomfort associated with digestion.

    Several studies have found that Lemon balm combined with other calming herbs helps reduce anxiety, stress, and promote sleep (1-4).

    In a double-blind, placebo-controlled study (2), 18 healthy participants received two separate single doses of a standardized lemon balm extract (300 mg and 600 mg) or placebo for 7 days. The 600 mg dose of lemon balm increased mood and significantly increased calmness and alertness.
    • 1. Cases J, Ibarra A, Feuillère N, Roller M, Sukkar SG. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Med J Nutrition Metab. 2011 Dec;4(3):211-218.
    • 2. Kennedy DO, Little W, Scholey AB. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med. 2004 Jul-Aug;66(4):607-13.
    • 3. Kennedy DO, Little W, Haskell CF, Scholey AB. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Phytother Res. 2006 Feb;20(2):96-102. PubMed
    • 4. Wheatley D. Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. J Psychopharmacol. 2005 Jul;19(4):414-21. PubMed
    • 5. Huang L, Abuhamdah S, Howes MJ, Dixon CL, Elliot MS, Ballard C, Holmes C, Burns A, Perry EK, Francis PT, Lees G, Chazot PL. Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels. J Pharm Pharmacol. 2008 Nov;60(11):1515-22. PubMed
  • 2. Lavandula angustifolia (Lavender)
    Lavender, a herb beloved for its pleasing fragrance, is an effective remedy for anxiety, depression, restlessness, and sleep problems.

    In the latest 2014 randomized, double-blind trial oral lavender oil preparation showed a pronounced antidepressant effect and improved general mental health and health-related quality of life in patients with in generalized anxiety disorder (9).

    Lavender aromatherapy is traditionally used for relaxation (2, 3). It is reported to help relieve anxiety in several small studies, although negative results have also been reported (4, 5).

    Preliminary research suggests that lavender may be helpful as an adjunct to prescription antidepressant medications (7).

    There is now scientific evidence that aromatherapy with lavender may slow the activity of the nervous system and improve sleep quality (1, 6). Extracts of Lavandula officinalis have potent sedative and hypnotic activities

    Research shows that the use of lavender oil is effective in reducing challenging behaviours in persons with dementia (8).
    • 1.  Lavender bath oil reduces stress and crying and enhances sleep in very young infants. Field T, Field T, Cullen C, Largie S, Diego M, Schanberg S, Kuhn C. Early Hum Dev. 2008 Jun;84(6):399-401. Epub 2007 Nov 28. PubMed
    • 2. The effect of foot-bath with or without the essential oil of lavender on the autonomic nervous system: a randomized trial. Saeki Y. Complement Ther Med. 2000 Mar;8(1):2-7. PubMed
    • 3. Lis-Balchin M, Hart S. Studies on the mode of action of the essential oil of lavender (Lavandula angustifolia P. Miller). Phytother Res. 1999 Sep;13(6):540-2. PubMed
    • 4. Shaw D, Annett JM, Doherty B, Leslie JC. Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats. Phytomedicine. 2007 Sep;14(9):613-20. Epub 2007 May 4. PubMed
    • 5. Rho KH, Han SH, Kim KS, et al. Effects of aromatherapy massage on anxiety and self-esteem in korean elderly women: a pilot study Int J Neurosci 2006 Dec;116(12):1447-55. PubMed
    • 6. Lewith GT, Godfrey AD, Prescott P. A single-blinded, randomized pilot study evaluating the aroma of Lavandula augustifolia as a treatment for mild insomnia. J Altern Complement Med. 2005 Aug;11(4):631-7. PubMed
    • 7. Akhondzadeh S, Kashani L, Fotouhi A, et al. Comparison of Lavandula angustifolia Mill. tincture and imipramine in the treatment of mild to moderate depression: a double-blind, randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 2003;27(1):123-127. PubMed
    • 8. van der Ploeg ES, Eppingstall B, O'Connor DW. The study protocol of a blinded randomised-controlled cross-over trial of lavender oil as a treatment of behavioural symptoms in dementia. BMC Geriatr. 2010 Jul 22;10:49. PubMed
    • 9. Kasper S, Gastpar M, Müller WE, Volz HP, Möller HJ, Schläfke S, Dienel A. Lavender oil preparation Silexan is effective in generalized anxiety disorder--a randomized, double-blind comparison to placebo and paroxetine. Int J Neuropsychopharmacol. 2014 Jun;17(6):859-69. PubMed
  • 3. Passiflora incarnata (Passion Flower)
    Purecalm also contains passion flower -- a herb with mild sedative effect. This property has been well-substantiated in numerous studies on animals and humans.
    Passion flower is used as a calming herb for anxiety (1, 3), insomnia, seizures (2), hysteria and other health problems related to anxiety and nervousness. Passion flower has been proven to reduce anxiety during the dental procedures (5).
    • 1. Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. Movafegh A, Alizadeh R, Hajimohamadi F, Esfehani F, Nejatfar M. Anesth Analg. 2008 Jun;106(6):1728-32
    • 2. Nassiri-Asl M, Shariati-Rad S, Zamansoltani F. Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors. BMC Complement Altern Med. 2007 Aug 8;7:26. PubMed
    • 3. Passiflora for anxiety disorder. Miyasaka LS, Atallah AN, Soares BG. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD004518. Review.
    • 4. Wheatley D. Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. Journal of Psychopharmacology. 2005 Jul;19(4):414-21. Review.
    • 5. Kaviani N, Tavakoli M, Tabanmehr M, Havaei R. The efficacy of passiflora incarnata linnaeus in reducing dental anxiety in patients undergoing periodontal treatment. J Dent (Shiraz). 2013 Jun;14(2):68-72. PubMed

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