UTI-Clear from Native Remedies is a herbal remedy for cystitis, bladder and urinary tract infections.

Because some types of urinary tract infections can deteriorate into serious or severe infections affecting the kidneys, therefore if the herbal supplements have not helped during this initial supplementation period, you should consult a qualified doctor for further diagnosis and treatment.

UTI-Clear Benefits

  • Stops burning when urinating, helps to flush out the bladder and urinate more easily
  • Reduces the need for frequent urination and eliminates inability to urinate even though you have the urge
  • Treats and prevents recurring cystitis
  • Assists with bloating as a diuretic

UTI-Clear Ingredients: Review of Scientific Evidence

Does UTI-Clear really work? HealthAssist has found scientific studies confirming the effectiveness of UTI-Clear herbal components. Take a look and make you own decision if the product worth a try.

  • 1. Agathosma betulina (Buchu)
    Buchu has been used traditionally cleanse the bladder and entire urinary tract system. Buchu has mild antibacterial, antispasmodic and diuretic activity. It is particularly useful in painful and burning urination. Buchu is used by herbalists as a part of herbal combinations for kidney and bladder problems.
    • 1. Lis-Balchin M, Hart S, Simpson E. Buchu (Agathosma betulina and A. crenulata, Rutaceae) essential oils: their pharmacological action on guinea-pig ileum and antimicrobial activity on microorganisms. J Pharm Pharmacol. 2001 Apr;53(4):579-82. PubMed
    • 2. Simpson D. Buchu--South Africa's amazing herbal remedy. Scott Med J. 1998 Dec;43(6):189-91. PubMed
  • 2. Arctostaphylos uva-ursi (Bearberry)
    Arctostaphylos uva ursi is one of the best natural urinary antiseptics and has historically been used as a remedy for urinary tract infections, cystitis, and kidney stones. In fact, until the discovery of sulfa drugs and antibiotics, uva ursi was the treatment of choice for bladder and urinary infections.

    Arbutin, the main active compound of uva ursi, is a phenolic glycoside that becomes hydrolyzed to hydroquinone. Both chemicals contribute to the antiseptic effects in the urinary tract. Arbutin alone has been reported to relieve pain from kidney stones, cystitis and nephritis (kidney inflammation).

    Clinical research proves use of uva ursi as an antiseptic and diuretic with soothing and strengthening properties:
    • 1. Schindler G, Patzak U, Brinkhaus B, von Niecieck A, Wittig J, Krähmer N, Glöckl I, Veit M. Urinary excretion and metabolism of arbutin after oral administration of Arctostaphylos uvae ursi extract as film-coated tablets and aqueous solution in healthy humans. J Clin Pharmacol. 2002 Aug;42(8):920-7.
    • 2. Jahodar L, Jilek P, Patkova M, Dvorakova V. Antimicrobial action of arbutin and the extract from the leaves of Arctostaphylos uva-ursi in vitro. Cesk Farm . 1985;34:174-178.
    • 3. Yarnell E. Botanical medicines for the urinary tract. World J Urol. 2002 Nov;20(5):285-93. Epub 2002 Oct 17. PubMed
    • 4. Stambergova A, Supcikova M, Leifertova I. Evaluation of phenolic substances in Arctostaphylos uva-ursi. Part 4. Determination of arbutin, methylarbutin and hydroquinone in the leaves by HPLC. Cesk Farm . 1985;34:179–182.
    • 5. Grases F, Melero G, Costa-Bauza A, Prieto R, March JG. Urolithiasis and phytotherapy. Int Urol Nephrol . 1994;26:507–511. PubMed
    • 6. Complete Uva Ursi information from Drugs.com
  • 3. Achillea millefolium (Yarrow)
    Another powerful ingredient in UTI-Clear is Achillea millefolium.
    Yarrow leaf (Achillea millefolium), named after Achilles, who used extracts of this plant to treat wounds, has been used as an antioxidant, anti-inflammatory, antiseptic, spasmolytic, haemostatic and digestive remedy.
    Yarrow contains alkamides and volatile oils rich in sesquiterpene lactones, which act as soothing agents and natural astringents. Yarrow is beneficial in supporting a healthy systemic environment within the bladder and urinary system.

    Moderate antibacterial activity has been documented for Achillea against Staphylococcus aureus, Streptococcus pneumoniae, Bacillus subtillus, Mycobacterium smegmatis, Escherichia coli, Shigella.
    • 1. Peng Y, Yan H, Wang SQ, Liu XT. 65 cases of urinary tract infection treated by total acid of Achillea alpina. J Tradit Chin Med. 1983 Sep;3(3):217-8.
    • 2. Tuberoso CI, Kowalczyk A, Coroneo V, Russo MT, Dessì S, Cabras P. Chemical composition and antioxidant, antimicrobial, and antifungal activities of the essential oil of Achillea ligustica all. J Agric Food Chem. 2005 Dec 28;53(26):10148-53.
    • 3. Benedek B, Kopp B. Achillea millefolium L. s.l. revisited: recent findings confirm the traditional use. Wien Med Wochenschr. 2007;157(13-14):312-4. PubMed
    • 4. Stojanović G, Radulović N, Hashimoto T, Palić R. In vitro antimicrobial activity of extracts of four Achillea species: the composition of Achillea clavennae L. (Asteraceae) extract. J Ethnopharmacol. 2005 Oct 3;101(1-3):185-90. PubMed
    • 5. Candan F, Unlu M, Tepe B, Daferera D, Polissiou M, Sökmen A, Akpulat HA. Antioxidant and antimicrobial activity of the essential oil and methanol extracts of Achillea millefolium subsp. millefolium Afan. (Asteraceae). J Ethnopharmacol. 2003 Aug;87(2-3):215-20.
    • 6. Falconieri D, Piras A, Porcedda S, Marongiu B, Gonçalves MJ, Cabral C, Cavaleiro C, Salgueiro L. Chemical composition and biological activity of the volatile extracts of Achillea millefolium. Nat Prod Commun. 2011 Oct;6(10):1527-30. PubMed
  • 4. Melissa officinalis (Lemon Balm)
    Lemon Balm is a valuable medicinal herb with potent antibacterial, antifungal, antiviral, and antioxidant effects. In vitro analyses of the antimicrobial properties of lemon balm suggested that the herb completely inhibits the growth of all yeast species.
    • 1. Mimica-Dukic N, Bozin B, Sokovic M, Simin N. Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil. J Agric Food Chem. 2004 May 5;52(9):2485-9. PubMed
    • 2. Canadanović-Brunet J, Cetković G, Djilas S, Tumbas V, Bogdanović G, Mandić A, Markov S, Cvetković D, Canadanović V. Radical scavenging, antibacterial, and antiproliferative activities of Melissa officinalis L. extracts. Journal of Medicinal Food. 2008 Mar;11(1):133-43. PubMed
    • 3. Hăncianu M, Aprotosoaie AC, Gille E, Poiată A, Tuchiluş C, Spac A, Stănescu U. Chemical composition and in vitro antimicrobial activity of essential oil of Melissa officinalis L. from Romania. Rev Med Chir Soc Med Nat Iasi. 2008 Jul-Sep;112(3):843-7. PubMed
  • 5. Avena sativa (Green Oats)
    Avena sativa, more commonly known as oats, has many medicinal properties. Oats contain more than 20 unique polyphenols, avenanthramides, which have shown strong antioxidant activity. Avena sativa has anti-inflammatory properties and may help to reduce itching.
    • 1. Sur R, Nigam A, Grote D, Liebel F, Southall MD. Avenanthramides, polyphenols from oats, exhibit anti-inflammatory and anti-itch activity. Arch Dermatol Res. 2008 Nov;300(10):569-74. May 7. PubMed
    • 2. Chu YF, Wise ML, Gulvady AA, Chang T, Kendra DF, Jan-Willem van Klinken B, Shi Y, O'Shea M. In vitro antioxidant capacity and anti-inflammatory activity of seven common oats. Food Chem. 2013 Aug 15;139(1-4):426-31. PubMed
  • 6. Hypericum perforatum (St. John’s wort)
    St. John’s wort has a broad spectrum of biological activities including antidepressant, anti-inflammatory and anti-oxidant effects. The herb has been considered a medicinally valuable plant for over 2000 years. Research suggests the effectiveness of St. John’s wort in treating inflammation-related disorders, bacterial and viral diseases, and as an antioxidant and neuroprotective agent.
    • 1. Uchida S, Hirai K, Hatanaka J, Hanato J, Umegaki K, Yamada S. Antinociceptive effects of St. John's wort, Harpagophytum procumbens extract and Grape seed proanthocyanidins extract in mice. Biol Pharm Bull. 2008 Feb;31(2):240-5. PubMed
    • 2. Tedeschi E, Menegazzi M, Margotto D, Suzuki H, Förstermann U, Kleinert H. Anti-inflammatory actions of St. John's wort: inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha (STAT-1alpha) activation. J Pharmacol Exp Ther. 2003 Oct;307(1):254-61. Epub 2003 Sep 3. PubMed
  • 7. Echinacea angustifolia
    Echinacea is a popular immune-system stimulant. Studies show (1-3) that echinacea enhances immune function is by enhancing the ability of macrophages to engulf and destroy foreign matter. The specific components of echinacea responsible for this effect are the polysaccharides, alkylamides, and cichoric acid.
    • 1. Sullivan AM, Laba JG, Moore JA, Lee TD. Echinacea-induced macrophage activation. Immunopharmacol Immunotoxicol. 2008;30(3):553-74. PubMed
    • 2. Rininger JA, Kickner S, Chigurupati P, McLean A, Franck Z. Immunopharmacological activity of Echinacea preparations following simulated digestion on murine macrophages and human peripheral blood mononuclear cells. J Leukoc Biol. 2000 Oct;68(4):503-10. PubMed
    • 3. Goel V, Lovlin R, Chang C, Slama JV, Barton R, Gahler R, Bauer R, Goonewardene L, Basu TK. A proprietary extract from the echinacea plant (Echinacea purpurea) enhances systemic immune response during a common cold. Phytother Res. 2005 Aug;19(8):689-94. PubMed
  • 8. Vaccinium myrtillus (Bilberry)
    Bilberry is used to treat diarrhea, menstrual cramps, eye problems, varicose veins, venous insufficiency, and other circulatory problems. Bilberries have powerful anti-inflammatory and antioxidant properties (1-2). Bilberry contains flavonoids called anthocyanosides, which are found largely in dark-skinned fruits, and act as potent antioxidants in the body.
    • 1. Chen J, Uto T, Tanigawa S, Kumamoto T, Fujii M, Hou DX. Expression profiling of genes targeted by bilberry (Vaccinium myrtillus) in macrophages through DNA microarray. Nutr Cancer. 2008;60 Suppl 1:43-50. PubMed
    • 2. Bao L, Yao XS, Yau CC, Tsi D, Chia CS, Nagai H, Kurihara H Protective effects of bilberry (Vaccinium myrtillus L.) extract on restraint stress-induced liver damage in mice. J Agric Food Chem. 2008 Sep 10;56(17):7803-7. Epub 2008 Aug 9. PubMed
    • 3. Puupponen-Pimiä R, Nohynek L, Ammann S, Oksman-Caldentey KM, Buchert J. Enzyme-assisted processing increases antimicrobial and antioxidant activity of bilberry. J Agric Food Chem. 2008 Feb 13;56(3):681-8. Epub 2008 Jan 23. PubMed

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